Synthesis of Nirmatrelvir: Development of a Scalable Cobalt-Catalyzed Cyclopropanation for Manufacture of the Bicyclic [3.1.0]Proline-Building Block-Reference-Cited by-同舟云学术

Synthesis of Nirmatrelvir: Development of a Scalable Cobalt-Catalyzed Cyclopropanation for Manufacture of the Bicyclic [3.1.0]Proline-Building Block

Published:2023-12-04 Issue:12 Volume:27 Page:2260-2270
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Algera Russell F.¹,Allais Christophe¹^ORCID,Baldwin Aaron F.²^ORCID,Busch Torsten³,Colombo Federica⁴,Colombo Matteo⁴,Depretz Christelle⁵,Dumond Yves René⁵,Faria Quintero Andres R.¹,Heredia Maria²,Jung Jörg³,Lall Amrita²,Lee Taegyo¹^ORCID,Liu Yizhou²,Mandelli Stefano⁴,Mantel Marvin³^ORCID,Morris Ronald²,Mustakis Jason¹^ORCID,Nguyen Bao²,Pearson Robert¹,Piper Jared L.¹,Ragan John A.¹^ORCID,Ruffin Brigitte⁵,Talicska Courtney²,Tcyrulnikov Sergei¹,Uyeda Christopher⁶^ORCID,Weekly R. Matthew¹,Zeng Ming²

Affiliation:

1. Chemical Research and Development, Pfizer Worldwide Research and Development, Groton Laboratories, Eastern Point Road, Groton, Connecticut 06340, United States

2. Analytical Research and Development, Pfizer Worldwide Research and Development, Groton Laboratories, Eastern Point Road, Groton, Connecticut 06340, United States

3. Curia Germany GmbH, Industriepark Höchst, D569, Frankfurt am Main 65926, Germany

4. Curia─Origgio, Viale Europa 5, Origgio 21040, Varese, Italy

5. Curia S.A.S., Zone Industrielle de Laville, Bon-Encontre 47240, France

6. Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.3c00251

Reference34 articles.

1. An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19