Points of Interest in the Chemistry of the Levomepromazine Drug Substance: Recycling of Undesired Enantiomer, Identification of New Phenothiazine Dimers, Synthesis of a Pharmacopeial Impurity, and an Unexpected Rearrangement-Reference-Cited by-同舟云学术

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Points of Interest in the Chemistry of the Levomepromazine Drug Substance: Recycling of Undesired Enantiomer, Identification of New Phenothiazine Dimers, Synthesis of a Pharmacopeial Impurity, and an Unexpected Rearrangement

Published:2024-01-02 Issue:1 Volume:28 Page:281-292
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Poszávácz László¹,Porcs-Makkay Márta¹,Halász Judit¹,Mórász Tamás²,Nagy Tamás¹,Kátai-Fadgyas Katalin¹,Simig Gyula¹,Volk Balázs¹^ORCID

Affiliation:

1. Egis Pharmaceuticals Plc., Directorate of Drug Substance Development, P.O. Box 100, H-1475 Budapest, Hungary

2. Egis Pharmaceuticals Plc., Technical Directorate, P.O. Box 100, H-1475 Budapest, Hungary

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.3c00368

Reference39 articles.

1. Jacob, R. M.; Robert, J. G. Phenthiazine compounds. U.S. Patent 2837518; Chem. Abstr. 1958, 52, 92978.

2. Benkó, P.; Budai, Z.; Budai, M. Z.; Magdányi, L.; Pallos, L. Phenothiazine derivatives. HU 155104 Hungarian Pat. Chem. Abstr. 1969, 70, 47474.

3. Nakanishi, M.; Hasegawa, G.; Phenothiazine compounds. JP 40009030 Japanese Pat. Chem. Abstr. 1965, 63, 31743.

4. Hansgeorg, E.; Friedrich, V.; Joachim, P. Optically active components for the synthesis of the side chain of (R,R,R)-alpha-tocopherol and process for their preparation. EP 0076448 Eur Pat. Chem. Abstr. 1983, 99, 22241.

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