Compact and Integrated Approach for Advanced End-to-End Production, Purification, and Aqueous Formulation of Lidocaine Hydrochloride

Author:

Monbaliu Jean-Christophe M.12,Stelzer Torsten13,Revalor Eve14,Weeranoppanant Nopphon1,Jensen Klavs F.1,Myerson Allan S.1

Affiliation:

1. Department of Chemical Engineering, Massachusetts Institute of Technology 77 Massachusetts Ave., Cambridge, Massachusetts 02139, United States

2. Center for Integrated Technology and Organic Synthesis, Department of Chemistry, University of Liège, B-4000 Liège (Sart Tilman), Belgium

3. Department of Pharmaceutical Sciences, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico, United States

4. Department of Chemical and Biomolecular Engineering, Melbourne Medical School, University of Melbourne, Melbourne, 3010 Victoria, Australia

Funder

SPAWAR Systems Center Pacific, Space and Naval Warfare Systems Command

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Reference28 articles.

1. Continuous Processing in the Manufacture of Active Pharmaceutical Ingredients and Finished Dosage Forms: An Industry Perspective

2. On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system

3. Key Green Engineering Research Areas for Sustainable Manufacturing: A Perspective from Pharmaceutical and Fine Chemicals Manufacturers

4. ACS. Sustainable U.S. Manufacturing in the Chemical and Allied Industrieshttps://www.acs.org/content/dam/acsorg/sustainability/acsandsustainability/sustainablemanufacturing/roadmaps/smrt-summary-sustainable-us-manufacturing-in-the-chemical-and-allied-industries-pdf.pdf(accessed April 20, 2016) .

5. The Reality of Drug Shortages — The Case of the Injectable Agent Propofol

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