Preparation of β-hydroxy-α-amino Acid Using Recombinant d-Threonine Aldolase

Author:

Goldberg Steven L.1,Goswami Animesh1,Guo Zhiwei1,Chan Yeung1,Lo Ehrlic T.1,Lee Andrew1,Truc Vu Chi1,Natalie Kenneth J.1,Hang Chao1,Rossano Lucius T.1,Schmidt Michael A.1

Affiliation:

1. Chemical Development, Bristol-Myers Squibb, One Squibb Drive, New Brunswick, New Jersey 08903, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Reference17 articles.

1. Donello, J. S., Schweighoffer, F. J., and Leblond, B.Methods for treating chronic pain using 3-aryl-3-hydroxy-2-amino-propionic acid amides, 3-heteroaryl-3-hydroxy-2-amino-propionic acid amides and related compounds. WO20080011478, 2008.

2. Leblond, B. B., Beausoleil, E., Taverne, T., and Donello, J. E.Methods of using as analgesics 1-benzyl-1-hydroxy-2,3-diamino-propyl amines, 3-benzyl-3-hydroxy-2-amino-propionic acid amides and related compounds. WO2006081273, 2006.

3. Threonine aldolases—screening, properties and applications in the synthesis of non-proteinogenic β-hydroxy-α-amino acids

4. Biocatalytic Synthesis of Natural and Non-Natural ��-Amino Acids

5. Threonine aldolases—an emerging tool for organic synthesis

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