Detection of Nucleation during Cooling Crystallization through Moving Window PCA Applied to in Situ Infrared Data

Author:

Taris Alessandra1,Hansen Thomas B.2ORCID,Rong Ben-Guang2ORCID,Grosso Massimiliano1ORCID,Qu Haiyan2

Affiliation:

1. Dipartimento Ingegneria Meccanica, Chimica e dei Materiali, Università degli Studi di Cagliari, Via Marengo 2, Cagliari, 09123, Italy

2. Department of Chemical Engineering, Biotechnology and Environmental Technology, University of Southern Denmark, Campusvej 55, 5230 Odense, Denmark

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Reference48 articles.

1. Guidance for Industry, PAT—a framework for innovative pharmaceuticalmanufacturing and quality assurance. U.S. Food and Drug Administration (FDA),Rockville MD, 2004.http://www.fda.gov/downloads/drugs/guidances/ucm070305.pdf(accessed on Jan 20, 2017).

2. Formation of Piroxicam Polymorphism in Solution Crystallization: Effect and Interplay of Operation Parameters

3. An investigation of the applicability of attenuated total reflection infrared spectroscopy for measurement of solubility and supersaturation of aqueous citric acid solutions

4. ATR FTIR spectroscopy for in situ measurement of supersaturation

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