Application of Biocatalytic Reductive Amination for the Synthesis of a Key Intermediate to a CDK 2/4/6 Inhibitor-Reference-Cited by-同舟云学术

Application of Biocatalytic Reductive Amination for the Synthesis of a Key Intermediate to a CDK 2/4/6 Inhibitor

Published:2021-09-03 Issue: Volume: Page:
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Duan Shengquan¹^ORCID,Widlicka Daniel W.¹^ORCID,Burns Michael P.¹^ORCID,Kumar Rajesh¹,Hotham Ian¹,Desrosiers Jean-Nicolas¹^ORCID,Bowles Paul¹,Jones Kris N.¹,Nicholson Lindsay D.¹,Buetti-Weekly Michele T.¹,Han Lu¹^ORCID,Steflik Jeremy¹,Hansen Eric¹,Hayward Cheryl M.¹,Strohmeyer Holly¹,Monfette Sébastien¹,Sutton Scott C.¹,Morris Christopher¹

Affiliation:

1. Chemical and Analytical Research and Development, Pfizer Worldwide Research and Development, Groton Laboratories, Groton, Connecticut 06340, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.1c00255

Reference25 articles.

1. Early Adaptation and Acquired Resistance to CDK4/6 Inhibition in Estrogen Receptor–Positive Breast Cancer

2. Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer

3. cBehenna, D. C.; Chen, P.; Freeman-Cook, K. D.; Hoffman, R. L.; Jalaie, M.; Nagata, A.; Nair, S. K.; Ninkovic, S.; Ornelas, M. A.; Palmer, C. L.; Rui, E. Y. CDK 2/4/6 inhibitors. U.S. Patent Appl. 10,233,188, WO Appl. 20180331815, 2018.

4. A radical chlorodifluoromethylation protocol for late-stage difluoromethylation and its application to an oncology candidate

5. Developing a Multistep Continuous Manufacturing Process for (1R,2R)-2-Amino-1-methylcyclopentan-1-ol

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