Discovery and Process Development of a Scalable Biocatalytic Kinetic Resolution toward Synthesis of a Sterically Hindered Chiral Ketone-Reference-Cited by-同舟云学术

Discovery and Process Development of a Scalable Biocatalytic Kinetic Resolution toward Synthesis of a Sterically Hindered Chiral Ketone

Published:2022-05-17 Issue:6 Volume:26 Page:1820-1830
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Wamser Nicole¹,Wu Hao¹^ORCID,Buono Frederic¹^ORCID,Brundage Anthony¹,Ricci Francesco¹,Lorenz Jon C.¹,Wang Jun¹,Haddad Nizar¹^ORCID,Paolillo Joshua¹^ORCID,Leung Joyce C.¹^ORCID,Lee Heewon¹,Hossain Azad¹

Affiliation:

1. Boehringer Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.2c00067

Reference49 articles.

1. Extending the application of biocatalysis to meet the challenges of drug development

2. Biocatalysis in Drug Development—Highlights of the Recent Patent Literature

3. Biocatalysis for synthesis of pharmaceuticals

4. Biocatalysis: A Pharma Perspective

5. The Hitchhiker's guide to biocatalysis: recent advances in the use of enzymes in organic synthesis

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