Preparation of the HIV Attachment Inhibitor BMS-663068. Part 8. Installation of the Phosphonoxymethyl Prodrug Moiety

Author:

Fox Richard J.1ORCID,Cohen Benjamin1,La Cruz Thomas E.1ORCID,Simpson James H.1,Freitag Adam1,Saurer Eric1,Tripp Jonathan C.1,Chen Chien-Kuang1,Beutner Gregory L.1ORCID,Rosso Victor W.1,Borgeson Elizabeth1,Glace Andrew W.1,Eastgate Martin D.1ORCID,Schild Richard L.1,Sweeney Jason T.1,Conlon David A.1

Affiliation:

1. Chemical & Synthetic Development, Bristol-Myers Squibb Company, One Squibb Drive, New Brunswick, New Jersey, 08903-0191, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Reference12 articles.

1. Preparation of the HIV Attachment Inhibitor BMS-663068. Part 1. Evolution of Enabling Strategies

2. Inhibitors of Human Immunodeficiency Virus Type 1 (HIV-1) Attachment. 5. An Evolution from Indole to Azaindoles Leading to the Discovery of 1-(4-Benzoylpiperazin-1-yl)-2-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione (BMS-488043), a Drug Candidate That Demonstrates Antiviral Activity in HIV-1-Infected Subjects

3. bLiu, W.; Patel, S. S.; Cuniere, N.; Lear, Y.; Deshpande, P. P.; Simon, J. N.; Lai, C.; Pullockaran, A. J.; Soundararajan, N.; Bien, J. T.US 2007/0032503, 2007.

4. cUeda, Y.; Connolly, T. P.; Kadow, J. A.; Meanwell, N. A.; Wang, T.; Chen, C–P. H.; Yeung, K – S.; Zhang, Z.; Leahy, D. K.; Pack, S. K.; Soundararajan, N.; Sirard, P.; Levesqu, K.; Thoraval, D.US 2005/0209246, 2005.

5. dSoundararajan, N.; Qiu, Y.; Hu, W.; Kronenthal, D. R.; Sirard, P.; Lajeunesse, J.; Droghini, R.; Chidambaram, R.; Qian, X.; Natalie, K. J.; Pack, S. K.; Reising, N.; Tang, E.; Fakes, M. G.; Gao, Q.; Qian, F.; Vakkalagadda, B. J.; Lai, C.; Kuang, S.M.US2006/0293304, 2006.

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