Comparison of a Batch and Flow Approach for the Lipase-Catalyzed Resolution of a Cyclopropanecarboxylate Ester, A Key Building Block for the Synthesis of Ticagrelor-Reference-Cited by-同舟云学术

Comparison of a Batch and Flow Approach for the Lipase-Catalyzed Resolution of a Cyclopropanecarboxylate Ester, A Key Building Block for the Synthesis of Ticagrelor

Published:2017-01-18 Issue:2 Volume:21 Page:195-199
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Hugentobler Katharina G.¹,Rasparini Marcello²,Thompson Lisa A.³,Jolley Katherine E.³,Blacker A. John³,Turner Nicholas J.¹^ORCID

Affiliation:

1. School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester M1 7DN, United Kingdom

2. Chemessentia, SRL - Via G. Bovio, 6-28100 Novara, Italy

3. Institute of Process Research and Development, School of Chemistry, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, United Kingdom

Funder

AstraZeneca

Engineering and Physical Sciences Research Council

Royal Society

Wolfson Foundation

Chemo Group

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.6b00346

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3. Clark, A.; Jones, E.; Larsson, U.; Mindis, A.Process for the Preparation of Cyclopropyl Carboxylic Acid Esters and Derivates. WO2001092200, 2001.

4. Dejonghe, J.P.; Peeters, K.; Renard, M.Chemical Process for Preparation of Aromatic Cyclopropane Esters and Amides. WO2008018822, 2008.

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