Control of Hydrogen Fluoride Formation and Release during a Large-Scale Nitroarene Reduction in the Manufacture of AZD9977-Reference-Cited by-同舟云学术

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Control of Hydrogen Fluoride Formation and Release during a Large-Scale Nitroarene Reduction in the Manufacture of AZD9977

Published:2022-12-28 Issue:1 Volume:27 Page:167-178
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Mallia Carl J.¹^ORCID,Le Bars Joël²,Hardy Simon¹,Lamacraft Alex²,Harding Simon²,Hose David²,Snow Lindsay¹,Poulten Rebecca C.¹,Dobson Benjamin C.³,Churchill Trevor³,Gillespie Paul M.³

Affiliation:

1. Early Chemical Development, Pharmaceutical Sciences, R&D, AstraZeneca, MacclesfieldSK10 2NA, U.K.

2. Chemical Development, Pharmaceutical Technology & Development, Operations, AstraZeneca, MacclesfieldSK10 2NA, U.K.

3. Clinical Manufacture & Supply, AstraZeneca, MacclesfieldSK10 2NA, U.K.

Funder

AstraZeneca

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.2c00323

Reference16 articles.

1. Nitro and related groups

2. Tin(II) Chloride

3. Simple and chemoselective reduction of aromatic nitro compounds to aromatic amines: reduction with hydriodic acid revisited

4. Runaway Reaction Hazards in Processing Organic Nitro Compounds

5. Managing Hazards for Scale Up of Chemical Manufacturing Processes

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Process Understanding Enables Control of Hydrogen Fluoride Formation in a Nitroarene Reduction;Synfacts;2023-03-17

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