Development of an Efficient Scale-Up Synthesis Method for a β3-Adrenergic Receptor Agonist, Ritobegron Ethyl Hydrochloride-Reference-Cited by-同舟云学术

Development of an Efficient Scale-Up Synthesis Method for a β3-Adrenergic Receptor Agonist, Ritobegron Ethyl Hydrochloride

Published:2020-07-31 Issue:9 Volume:24 Page:1675-1682
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Sonehara Junichi¹²,Isawa Hidetoshi³,Kasai Kiyoshi³,Kikuchi Norihiko³,Ishikawa Takehiro⁴,Kobayashi Masahiro³,Ozawa Tetsuji³,Suzuki Ritsu²,Kobayashi Makoto²,Ainai Takayuki²,Nishimura Masayuki²,Saito Yohei¹,Nakagawa-Goto Kyoko¹⁵^ORCID

Affiliation:

1. School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa 920-1192, Japan

2. Joetsu Chemical Laboratories, Kissei Pharmaceutical Co., Ltd., 197-5 Kamiyoshi, Kubiki, Joetsu, Niigata 942-0145, Japan

3. Head Office, Kissei Pharmaceutical Co., Ltd., 19-48 Yoshino, Matsumoto, Nagano 399-8710, Japan

4. Central Research Laboratories, Kissei Pharmaceutical Co., Ltd., 4365-1 Hotakakashiwabara, Azumino, Nagano 399-8304, Japan

5. UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7568, United States

Funder

Japan Society for the Promotion of Science

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.0c00278

Reference17 articles.

1. Discovery of Vibegron: A Potent and Selective β3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder

2. Early investigational β3 adreno-receptor agonists for the management of the overactive bladder syndrome

3. Pharmacological profile of β3-adrenoceptor agonists in clinical development for the treatment of overactive bladder syndrome

4. Selective β3-Adrenoceptor Agonists for the Treatment of Overactive Bladder

5. Bladder selectivity of the novel β3-agonist ritobegron (KUC-7483) explored by in vitro and in vivo studies in the rat

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1. Synthesis of Ritobegron Ethyl Hydrochloride;Synfacts;2020-11-17