Preparation of the HIV Attachment Inhibitor BMS-663068. Part 5. Selective C-7 Bromination of the 6-Azaindole Core-Reference-Cited by-同舟云学术

Preparation of the HIV Attachment Inhibitor BMS-663068. Part 5. Selective C-7 Bromination of the 6-Azaindole Core

Published:2017-08-09 Issue:8 Volume:21 Page:1137-1144
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

González-Bobes Francisco¹^ORCID,Hickey Matthew R.¹,Cohen Benjamin¹,Bultman Michael¹,Chen Ke¹,Fanfair Dayne¹,Rosso Victor W.¹,Strotman Neil A.¹^ORCID,Mudryk Boguslaw¹,Murugesan Saravanababu¹,Schild Richard L.¹,Ivy Sabrina¹,Eastgate Martin D.¹^ORCID,Sweeney Jason T.¹,Conlon David A.¹

Affiliation:

1. Chemical and Synthetic Development, Bristol-Myers Squibb Company, One Squibb Drive, New Brunswick, New Jersey 08903-0191, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.7b00132

Reference48 articles.

1. Synthesis of the 6-Azaindole Containing HIV-1 Attachment Inhibitor Pro-Drug, BMS-663068

2. bEastgate, M. D.; Bultman, M. S.; Chen, K. C.; Fanfair, D. D.; Fox, R. J.; La Cruz, T. E.; Mudryk, B. M.; Risatti, C. A.; Simpson, J. H.; Soumeillant, M. C.; Tripp, J. C.; Xiao, Y.Methods for the Preparation of HIV Attachment Inhibitor Piperazine Prodrug Compound. U.S. Patent 2013/0203992.

3. Site-Selective Azaindole Arylation at the Azine and Azole Rings via N-Oxide Activation

4. Recent trends in the chemistry of pyridine N-oxide

5. A Simple and Efficient Method for the Preparation of Pyridine N-Oxides

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