One-Pot Process for Synthesis of Nalbuphine Hydrochloride and Impurity Control Strategy-Reference-Cited by-同舟云学术

One-Pot Process for Synthesis of Nalbuphine Hydrochloride and Impurity Control Strategy

Published:2020-08-07 Issue:9 Volume:24 Page:1707-1717
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Zhang Tao¹²,Wu Zenong¹²,Chen Yibo²,Zhao Weili¹^ORCID,Yang Zhezhou²,Zhang Fuli²^ORCID

Affiliation:

1. School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, P. R. China

2. Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, 285 Gebaini Road, Pudong, Shanghai 201203, P. R. China

Funder

Engineering Research Center for Improvement and Industrialization of Pharmaceutical Processes

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.0c00321

Reference30 articles.

1. Ceiling effect for respiratory depression by nalbuphine

2. aPachter, J. P.; Zaven, M. N-Substituted-14-Hydroxydihydro-Normorphines. U.S. Patent US3,393,1971968.

3. bKavka, F. Preparation of Nalbuphine Having Low Levels of Beta-Epimer. U.S. Patent US5,756,7451995.

4. dGrote, C. W.; Wang, P. X.; Jiang, T.; Cantrell, G. L.; Moster, F. W.; Thomasson, C. E. Improved Process for the Preparation of 6-Alpha-Hydroxy-N-Alkylated Opiates. WO2008137672A12008.

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