Early Development, Scale-Up, and Reverse-Phase Purification of a Highly Potent Pyrrolobenzodiazepine Dimer, SG3259, for Use in Antibody

Early Development, Scale-Up, and Reverse-Phase Purification of a Highly Potent Pyrrolobenzodiazepine Dimer, SG3259, for Use in Antibody–Drug Conjugates

Published:2021-04-08 Issue:4 Volume:25 Page:799-809
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Holte Dane¹^ORCID,Rao Meera²,Huters Alexander³,Simanis Justin³,Califano Jean-Christophe³,Kempema Aaron²,Levy Jean-Noel²

Affiliation:

1. AbbVie Process Research and Development, 995 East Arques Avenue, Sunnyvale, California 94085, United States

2. AbbVie Research & Development, 450 East Jamie Court, South San Francisco, California 94080, United States

3. AbbVie Process Research and Development, 1 North Waukegan Road, North Chicago, Illinois 60064, United States

Funder

AbbVie

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.0c00497

Reference23 articles.

1. Synthesis of DNA-Interactive Pyrrolo[2,1-c][1,4]benzodiazepines (PBDs)

2. From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody-Drug Conjugates (ADCs)

3. Howard, P. W. Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation. U. S. Patent 9,745,303 B2, Aug. 29, 2017.

4. Solution Structure of a 2:1 C2-(2-Naphthyl) Pyrrolo[2,1-c][1,4]benzodiazepine DNA Adduct: Molecular Basis for Unexpectedly High DNA Helix Stabilization

5. Biosynthesis, synthesis, and biological activities of pyrrolobenzodiazepines

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