Practical Asymmetric Synthesis of an Edivoxetine·HCl Intermediate via an Efficient Diazotization Process-Reference-Cited by-同舟云学术

Practical Asymmetric Synthesis of an Edivoxetine·HCl Intermediate via an Efficient Diazotization Process

Published:2015-04-02 Issue:4 Volume:19 Page:543-550
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Kopach Michael E.¹,Heath Perry C.¹,Scherer Roger B.¹,Pietz Mark A.¹,Astleford Bret A.¹,McCauley Mary Kay¹,Singh Utpal K¹,Wong Sze Wing¹,Coppert David M.¹,Kerr Mark S.¹,Houghton Peter G.¹,Rhodes Gary A.²,Tharp Gregg A.³

Affiliation:

1. Small Molecule Design and Development, Eli Lilly and Company, Indianapolis, Indiana 46285, United States

2. Technical Services & Manufacturing Science, Elanco External Manufacturing & Commercialization, Greenfield, Indiana 46140, United States

3. Manufacturing Technical Services, Eli Lilly and Company, Indianapolis, Indiana 46285, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.5b00014

Reference27 articles.

1. Practical Synthesis of Chiral 2-Morpholine: (4-Benzylmorpholin-2-(S)-yl)-(tetrahydropyran-4-yl)methanone Mesylate, a Useful Pharmaceutical Intermediate

2. The continuous flow Barbier reaction: an improved environmental alternative to the Grignard reaction?

3. The synthesis of 2-morpholine carboxylic acid derivatives and their elaboration to 1-aza-4-oxabicyclo[3.3.1]nonan-6-one.

4. Discovery of novel and selective tertiary alcohol containing inhibitors of the norepinephrine transporter

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