A Novel and Practical Synthesis of Mavorixafor-Reference-Cited by-同舟云学术

A Novel and Practical Synthesis of Mavorixafor

Published:2022-06-09 Issue:6 Volume:26 Page:1831-1836
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Liu Weiyuan¹^ORCID,Bi Siju¹,Tian Ting¹,Zhou Ting¹,Lin Kuaile¹,Zhou Weicheng¹

Affiliation:

1. State Key Lab of New Drug & Pharmaceutical Process, Shanghai Key Lab of Anti-Infectives, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, No. 285 Gebaini Road, Shanghai 201203, P. R. China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.2c00076

Reference14 articles.

1. AMD070, a CXCR4 Chemokine Receptor Antagonist: Practical Large-Scale Laboratory Synthesis

2. Results of a phase 2 trial of an oral CXCR4 antagonist, mavorixafor, for treatment of WHIM syndrome

3. Biased action of the CXCR4-targeting drug plerixafor is essential for its superior hematopoietic stem cell mobilization

4. Crawford, J. B.; Chen, G.; Gauthier, D.; Skerlj, R.; Baird, I. R.; Wilson, T. R. Process for the synthesis of CXCR4 antagonist. US 2005/0209277 A1, September 22, 2005.

5. McEachern, E. J.; Bridger, G. J.; Skupinska, K. A.; Skerlj, R. T. Synthesis of enantiomerically pure amino-substituted fused bicyclic rings. WO 2003022785 A2, March 20, 2003.

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