Process Safety Considerations for the Supply of a High-Energy Oxadiazole IDO1-Selective Inhibitor-Reference-Cited by-同舟云学术

Process Safety Considerations for the Supply of a High-Energy Oxadiazole IDO1-Selective Inhibitor

Published:2019-05-28 Issue:6 Volume:23 Page:1178-1190
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Martinot Theodore A.¹^ORCID,Ardolino Michael¹^ORCID,Chen Lu²,Lam Yu-hong³,Li Chaomin¹,Maddess Matthew L.¹^ORCID,Muzzio Daniel⁴,Qi Ji⁴^ORCID,Saurí Josep¹,Song Zhiguo J.⁴^ORCID,Tan Lushi⁴,Vickery Thomas⁴,Yin Jingjun⁴,Zhao Ralph⁴

Affiliation:

1. Process Research & Development, MRL, Merck & Co., Inc., Boston, Massachusetts 02115, United States

2. WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China

3. Modeling and Informatics, MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States

4. Process Research & Development, MRL, Merck & Co., Inc., Rahway, New Jersey 07065, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.9b00105

Reference43 articles.

1. Pembrolizumab versus Ipilimumab in Advanced Melanoma

2. Prevention of Allogeneic Fetal Rejection by Tryptophan Catabolism

3. IDO and tolerance to tumors

4. Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase

5. Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8+ T cells directly within the tumor microenvironment

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