Development of a Practical and Scalable Synthetic Route for the Adenosine Monophosphate-Activated Protein Kinase Activator, ASP4132-Reference-Cited by-同舟云学术

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Development of a Practical and Scalable Synthetic Route for the Adenosine Monophosphate-Activated Protein Kinase Activator, ASP4132

Published:2021-12-09 Issue:12 Volume:25 Page:2786-2794
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Tajima Takayoshi¹^ORCID,Hoshii Hiroaki²,Kohmura Yoshinori²

Affiliation:

1. Chemical & Biological Technology Laboratories, Astellas Pharma Inc., 160-2 Akahama, Takahagi-shi, Ibaraki 318-0001, Japan

2. Pharmaceutical Science & Technology Laboratories, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba-shi, Ibaraki 305-8585, Japan

Funder

Astellas Pharma

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.1c00392

Reference21 articles.

1. AMP-activated protein kinase: the current landscape for drug development

2. AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism

3. AMPK-beta1 subunit is a p53-independent stress responsive protein that inhibits tumor cell growth upon forced expression

4. Down-regulation of adenosine monophosphate–activated protein kinase activity: A driver of cancer

5. Development of a potent and orally active activator of adenosine monophosphate-activated protein kinase (AMPK), ASP4132, as a clinical candidate for the treatment of human cancer

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1. Palladium Extraction Following Metal-Catalyzed Reactions: Recent Advances and Applications in the Pharmaceutical Industry;Organic Process Research & Development;2023-09-06

2. Large-Scale Amidations in Process Chemistry: Practical Considerations for Reagent Selection and Reaction Execution;Organic Process Research & Development;2022-06-07

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