An Alternative Scalable Process for the Synthesis of 4,6-Dichloropyrimidine-5-carbonitrile

Author:

Zhang Bin1ORCID,Yan Huixin1,Ge Chongfeng1,Liu Bo1ORCID,Wu Zhenping1

Affiliation:

1. Hutchison MediPharma, Zhangjiang Hi-Tech Park, Shanghai 201203, P. R. China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Reference20 articles.

1. Herbicidal activity of heterocyclic dichlobenil analogues

2. Bamba, M.; Muraki, T.; Takashima, S.; Kobashi, Y. Preparation of 4-(propargylamino)pyrimidine-5-carbonitrile derivatives as pest-control agents for use in agriculture and horticulture. WO2012096061A1, 2012.

3. Kuragano, T.; Tanaka, Y. Preparation of 4-phenyl or heterocyclylpyrimidine derivatives and herbicides containing the same. WO2002038550A1, 2002.

4. Yamada, H.; Okawa, A. Manufacture of imidazoles and imidazomalononitriles for color couplers. JP2002145866A, 2002.

5. Tao, C.; Wang, Q.; Nallan, L.; Ho, D.; Polat, T.; Arp, F.; Weingarten, P. Preparation of pyrimidine derivatives as kinase inhibitors and therapeutic applications thereof. WO2016137506A1, 2016.

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