Scalable Synthesis of CVN424, an Inverse Agonist of the GPR6 Receptor
Author:
Affiliation:
1. Pharmaron Beijing Co., Ltd., No. 6, TaiHe Road, BDA, Beijing 100176, China
2. Cerevance Ltd, 418 Cambridge Science Park, Milton Road, Cambridge CB4 0PZ, U.K.
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.2c00181
Reference10 articles.
1. First-Time Disclosure of CVN424, a Potent and Selective GPR6 Inverse Agonist for the Treatment of Parkinson’s Disease: Discovery, Pharmacological Validation, and Identification of a Clinical Candidate
2. Species and cell-type properties of classically defined human and rodent neurons and glia
3. Development of CVN424: A Selective and Novel GPR6 Inverse Agonist Effective in Models of Parkinson Disease
4. A Phase I, First-in-Human, Healthy Volunteer Study to Investigate the Safety, Tolerability, and Pharmacokinetics of CVN424, a Novel G Protein-Coupled Receptor 6 Inverse Agonist for Parkinson’s Disease
5. Brown, J.; Hitchcock, S.; Hopkins, M.; Kikuchi, S.; Monenschein, H.; Reichard, H.; Schleicher, K.; Sun, H.; Macklin, T. Tetrahydropyridopyrazines modulators of GPR6. WO 2015095728 A1, 2015.
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