Development of an Efficient and Scalable Biocatalytic Route to (1S,4R)-8-Hydroxy-1,2,3,4- tetrahydro-1,4-methanonaphthalen-5-yl Propionate via Enantioselective Enzymatic Desymmetrization of a Prochiral Diester-Reference-Cited by-同舟云学术

Development of an Efficient and Scalable Biocatalytic Route to (1S,4R)-8-Hydroxy-1,2,3,4- tetrahydro-1,4-methanonaphthalen-5-yl Propionate via Enantioselective Enzymatic Desymmetrization of a Prochiral Diester

Published:2019-05-13 Issue:6 Volume:23 Page:1243-1251
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Feng Yahui¹,Wang Zhongqing²^ORCID,Luo Zhonghua¹,Lai Jinqiang²^ORCID,Xie Hongming²³,Luo Zhenxiu²,Zhang Lei¹^ORCID,Li Ridong⁴,Zhang Yingjun²³

Affiliation:

1. School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510640, P. R. China

2. HEC Research and Development Center, HEC Pharm Group, Dongguan 523871, P. R. China

3. Anti-infection Innovation Department, New Drug Research Institute, HEC Pharm Group, Dongguan 523871, P. R. China

4. Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University, Beijing 100191, P. R. China

Funder

Ministry of Science and Technology of the People's Republic of China

Ministry of Education of the People's Republic of China

State Key Laboratory of Anti-infective Drug Development, Sunshine Lake Pharmaceutical Co. LTD.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.9b00188

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