Development of an Improved Route for the Synthesis of an Abemaciclib Intermediate-Reference-Cited by-同舟云学术

Development of an Improved Route for the Synthesis of an Abemaciclib Intermediate

Published:2019-10-23 Issue:11 Volume:23 Page:2549-2555
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Carroll Michael P.¹,Moloney Harold¹^ORCID,Gowran Olivia²,O’Connor Aoibheann¹,Wilson Eoin M.¹,Murray Michael M.¹,Pietz Mark A.³,Kjell Douglas P.³,Held C. Brad³,Frederick Michael O.³^ORCID

Affiliation:

1. Technical Services/Manufacturing Science, Eli Lilly Kinsale, Limited, Dunderrow, Kinsale, P17 NY71, County Cork, Ireland

2. Quality Control Laboratories, Eli Lilly Kinsale, Limited, Dunderrow, Kinsale, P17 NY71, County Cork, Ireland

3. Small Molecule Design and Development, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.9b00347

Reference17 articles.

1. MONARCH 3: Abemaciclib As Initial Therapy for Advanced Breast Cancer

2. MONARCH 3 final PFS: a randomized study of abemaciclib as initial therapy for advanced breast cancer

3. Development of a Leuckart–Wallach Reaction in Flow for the Synthesis of Abemaciclib

4. A synthesis of abemaciclib utilizing a Leuckart–Wallach reaction

5. Ueber eine neue Bildungsweise von Tribenzylamin

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