Drug-Linkers in Antibody–Drug Conjugates: Perspective on Current Industry Practices

Author:

Bulger Paul G.1ORCID,Conlon David A.2ORCID,Cink Russell D.3ORCID,Fernandez-Cerezo Lara4ORCID,Zhang Qunying5,Thirumalairajan Srinath6,Raglione Thomas7,Liang Ruiting8,Zhou Jinsheng9,Chalgeri Arun10

Affiliation:

1. Department of Analytical Research & Development, Merck & Co., Inc., 126 E. Lincoln Avenue, Rahway, New Jersey 07065, United States

2. Conlon Pharma Consulting, Easton, Pennsylvania 18045, United States

3. Process Research & Development, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States

4. Department of Process Research & Development, Merck & Co., Inc., 126 E. Lincoln Avenue, Rahway, New Jersey 07065, United States

5. Analytical Research & Development, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States

6. Chemical Process and Analytical Development, Seagen Inc., 22515 29th Dr SE, Bothell, Washington 98021, United States

7. Chemical Process Development, Bristol-Myers Squibb, New Brunswick, New Jersey 08903, United States

8. Analytical Research & Development, BeiGene, Inc., 30 Science Park Road, Beijing 102206, China

9. Synthetic Molecule Design and Development, Eli Lilly and Company, Indianapolis, Indiana 46225, United States

10. Regulatory Affairs CMC, Daiichi Sankyo Inc., 211 Mount Airy Road, Basking Ridge, New Jersey 07920, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Reference45 articles.

1. Please visit www.iqconsortium.org for more information.

2. New Drugs at FDA: CDER’s New Molecular Entities and New Therapeutic Biological Products. https://www.fda.gov/drugs/development-approval-process-drugs/new-drugs-fda-cders-new-molecular-entities-and-new-therapeutic-biological-products (accessed December 29, 2022).

3. An Insight into FDA Approved Antibody-Drug Conjugates for Cancer Therapy

4. Antibody drug conjugate: the “biological missile” for targeted cancer therapy

5. Unlocking the potential of antibody–drug conjugates for cancer therapy

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