Improved Manufacturing Route and Polymorphic Control of a Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor ASP3026-Reference-Cited by-同舟云学术

Improved Manufacturing Route and Polymorphic Control of a Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor ASP3026

Published:2019-02-20 Issue:4 Volume:23 Page:512-523
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Takahama Yuji¹^ORCID,Obitsu Kazuyoshi¹,Takeguchi Kazuhiro¹,Hirasawa Shun¹,Kobayashi Koji¹,Akiba Takahiro¹,Ueda Norihiro¹,Orii Ryoki¹,Ohigashi Atsushi¹,Takahashi Takumi¹,Okada Minoru¹,Ieda Shigeru¹

Affiliation:

1. Process Chemistry Laboratories, Astellas Pharma Inc., 160-2 Akahama, Takahagi-shi, Ibaraki 318-0001, Japan

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.8b00427

Reference17 articles.

1. Fusion of a Kinase Gene, ALK , to a Nucleolar Protein Gene, NPM , in Non-Hodgkin's Lymphoma

2. Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer

3. Non-solid oncogenes in solid tumors:EML4-ALKfusion genes in lung cancer

4. A mouse model for EML4-ALK-positive lung cancer

5. Targeting Anaplastic Lymphoma Kinase in Lung Cancer: Figure 1.

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