Streamlined Synthesis of SHP2 Inhibitor GDC-1971 Enhanced by a Telescoped Schotten-Baumann SNAr and Reactive Crystallization Cascade
Author:
Affiliation:
1. Department of Synthetic Molecule Process Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States
Publisher
American Chemical Society (ACS)
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.4c00162
Reference28 articles.
1. Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors
2. Recent Advances of SHP2 Inhibitors in Cancer Therapy: Current Development and Clinical Application
3. Emerging Therapeutic Approaches of SHP2-Targeted Modulators
4. See reports of ongoing PhI trials at https://www.clinicaltrials.gov; for example:
5. Taylor, A. M.; Lescarbeau, A.; Wang, J.; Zhang, Y.; Lian, G. SHP2 Phosphatase Inhibitors and Methods of Making and Using the Same, U.S. Patent 11,890,281 B2, 2021.
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