Development of a Scalable Electrophilic Amination Protocol for the Multi-kg Production of 5-Methyl-2-pyridinesulfonamide: A Regulatory Starting Material of Endothelin Receptor Antagonist Clazosentan-Reference-Cited by-同舟云学术

Development of a Scalable Electrophilic Amination Protocol for the Multi-kg Production of 5-Methyl-2-pyridinesulfonamide: A Regulatory Starting Material of Endothelin Receptor Antagonist Clazosentan

Published:2023-06-23 Issue:7 Volume:27 Page:1377-1383
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Schäfer Gabriel¹^ORCID,Fleischer Tony¹,Kastner Matthias¹,Karge Reinhard¹,Huang Qi²,Wu Bruce Libang²,Tang Jun²,Aiglstorfer Iris³

Affiliation:

1. Chemistry Process R&D, Idorsia Pharmaceuticals Ltd., Hegenheimermattweg 91, CH-4123 Allschwil, Switzerland

2. Carbogen Amcis (Shanghai) Co., Ltd., No. 69 Shungong Road, Shanghai Chemical Industry Park, 201507 Shanghai, China

3. Carbogen Amcis AG, Hauptstrasse 171, CH-4416 Bubendorf, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.3c00131

Reference23 articles.

1. Clinical and experimental aspects of aneurysmal subarachnoid hemorrhage

2. A review of cerebral vasospasm in aneurysmal subarachnoid haemorrhage Part I: Incidence and effects

3. Clazosentan to Overcome Neurological Ischemia and Infarction Occurring After Subarachnoid Hemorrhage (CONSCIOUS-1)

4. Clazosentan, an endothelin receptor antagonist, in patients with aneurysmal subarachnoid haemorrhage undergoing surgical clipping: a randomised, double-blind, placebo-controlled phase 3 trial (CONSCIOUS-2)

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