Application of the Polonovski Reaction: Scale-up of an Efficient and Environmentally Benign Opioid Demethylation
Author:
Affiliation:
1. CatSci Ltd., CBTC2, Capital Business Park, Wentloog, Cardiff CF3 2PX, U.K.
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.1c00462
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1. Advances in Development of Dopaminergic Aporphinoids
2. Therapeutic and Diagnostic Agents for Parkinson's Disease
3. Synthesis and Dopamine Receptor Affinities of N-Alkyl-11-hydroxy-2-methoxynoraporphines: N-Alkyl Substituents Determine D1 versus D2 Receptor Selectivity
4. Synthesis and neuropharmacological evaluation of esters of R(−)-N-alkyl-11-hydroxy-2-methoxynoraporphines
5. An investigation of the N-demethylation of 3-deoxymorphine and the affinity of the alkylation products to μ, δ, and κ receptors
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