Development of a Safe Process for Manufacturing of the Potent Anticancer Agent Melflufen Hydrochloride-Reference-Cited by-同舟云学术

Development of a Safe Process for Manufacturing of the Potent Anticancer Agent Melflufen Hydrochloride

Published:2019-05-13 Issue:6 Volume:23 Page:1191-1196
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Cotton Hanna¹^ORCID,Bäckström Birthe¹,Fritzson Ingela¹,Lehmann Fredrik²,Monemi Taraneh¹,Oltner Viveca¹,Sölver Ellen¹,Wahlström Niklas¹^ORCID,Wennerberg Johan¹^ORCID

Affiliation:

1. Magle Chemoswed, Agneslundsvägen 27, SE, 212 15 Malmö, Sweden

2. Recipharm OT Chemistry, Virdings Allé 32 B, 754 50 Uppsala, Sweden

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.9b00116

Reference15 articles.

1. First-in-human, phase I/IIa clinical study of the peptidase potentiated alkylator melflufen administered every three weeks to patients with advanced solid tumor malignancies

2. The novel alkylating prodrug melflufen (J1) inhibits angiogenesis in vitro and in vivo

3. Structure–Activity Relationship for Alkylating Dipeptide Nitrogen Mustard Derivatives

4. Synthesis of ketobemidone precursorsviaphase-transfer catalysis

5. Improving the Potency of Cancer Immunotherapy by Dual Targeting of IDO1 and DNA

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