Development of a Large-Scale Route to Glecaprevir: Synthesis of the Side Chain and Final Assembly-Reference-Cited by-同舟云学术

Development of a Large-Scale Route to Glecaprevir: Synthesis of the Side Chain and Final Assembly

Published:2020-07-13 Issue:8 Volume:24 Page:1393-1404
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Hill David R.¹,Abrahamson Michael J.²,Lukin Kirill A.¹,Towne Timothy B.¹,Engstrom Kenneth M.¹^ORCID,Reddy Rajarathnam E.²,Kielbus Angelica B.²,Pelc Matthew J.¹,Mei Jianzhang¹,Nere Nandkishor K.¹,Chen Shuang¹,Henry Rodger¹,Chemburkar Sanjay²,Ding Chen³,Zhang Hongqiang³,Cink Russell D.¹^ORCID

Affiliation:

1. Process Research & Development, AbbVie Inc., 1401 Sheridan Road, North Chicago, Illinois 60064, United States

2. Operations Science & Technology, AbbVie Inc., 1401 Sheridan Road, North Chicago, Illinois 60064, United States

3. Analytical Research & Development, AbbVie Inc., 1401 Sheridan Road, North Chicago, Illinois 60064, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.0c00245

Reference25 articles.

1. Development of the Enabling Route for Glecaprevir via Ring-Closing Metathesis

2. Development of a Large-Scale Route to Glecaprevir: Synthesis of the Macrocycle via Intramolecular Etherification

3. Concise Synthesis of Acyl Migration-Blocked 1,1-Difluorinated Analogues of Lysophosphatidic Acid

4. New fluorinating reagents. Dialkylaminosulfur fluorides

5. Bis(2-methoxyethyl)aminosulfur Trifluoride: A New Broad-Spectrum Deoxofluorinating Agent with Enhanced Thermal Stability

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