Development of a Synthesis of Kinase Inhibitor AKN028-Reference-Cited by-同舟云学术

Development of a Synthesis of Kinase Inhibitor AKN028

Published:2018-09-17 Issue:10 Volume:22 Page:1360-1364
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Bremberg Ulf¹,Eriksson-Bajtner Johan²,Lehmann Fredrik¹,Oltner Viveca²,Sölver Ellen²,Wennerberg Johan²^ORCID

Affiliation:

1. Recipharm OT Chemistry, Virdings Allé 32 B, SE 754 50 Uppsala, Sweden

2. R&D Department, Magle Chemoswed, P.O. Box 839, SE 201 80 Malmö, Sweden

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.8b00092

Reference11 articles.

1. The novel tyrosine kinase inhibitor AKN-028 has significant antileukemic activity in cell lines and primary cultures of acute myeloid leukemia

2. AKN-028 induces cell cycle arrest, downregulation of Myc associated genes and dose dependent reduction of tyrosine kinase activity in acute myeloid leukemia

3. Jenmalm-Jensen, A.; Lehmann, F.; Nilsson, B. M.; Nordling, E.; Parrow, V. Pyrazine derivatives and their use as protein kinase inhibitors. PCT Int. Appl. WO/2009095399, July 6, 2009.

4. Lehmann, F.; Bremberg, U.; Sölver, E.; Eriksson-Bajtner, J.; Thornqvist-Oltner, V. Processes for manufacturing of a kinase inhibitor. PCT Int. Appl. WO/2013089636, June 20, 2013.

5. Discovery, Synthesis, and Characterization of an Orally Bioavailable, Brain Penetrant Inhibitor of Mixed Lineage Kinase 3

Cited by 7 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Natural Products–Pyrazine Hybrids: A Review of Developments in Medicinal Chemistry;Molecules;2023-11-05

2. Palladium Extraction Following Metal-Catalyzed Reactions: Recent Advances and Applications in the Pharmaceutical Industry;Organic Process Research & Development;2023-09-06

3. Pyrazine and Phenazine Heterocycles: Platforms for Total Synthesis and Drug Discovery;Molecules;2022-02-07

4. A broadly applicable quantitative relative reactivity model for nucleophilic aromatic substitution (S_NAr) using simple descriptors;Chemical Science;2022

5. Pyrazines and Their Benzo Derivatives;Comprehensive Heterocyclic Chemistry IV;2022