Development and Manufacture of a Curtius Rearrangement Using Continuous Flow towards the Large-Scale Manufacture of AZD7648-Reference-Cited by-同舟云学术

Development and Manufacture of a Curtius Rearrangement Using Continuous Flow towards the Large-Scale Manufacture of AZD7648

Published:2022-11-15 Issue:12 Volume:26 Page:3312-3322
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Mallia Carl J.¹^ORCID,McCreanor Niall G.²,Legg Daniel H.¹,Stewart Craig R.¹,Coppock Sarah¹,Ashworth Ian W.²^ORCID,Le Bars Joël²,Clarke Adam²,Clemens Graeme²,Fisk Heidi²,Benson Helen¹,Oke Samantha²,Churchill Trevor²,Hoyle Mark²^ORCID,Timms Lee¹,Vare Kevin¹,Sims Martin¹,Knight Steven¹

Affiliation:

1. Early Chemical Development, Pharmaceutical Sciences, R&D, AstraZeneca, Macclesfield SK10 2NA, U.K.

2. Chemical Development, Pharmaceutical Technology & Development, Operations, AstraZeneca, Macclesfield SK10 2NA, U.K.

Funder

AstraZeneca

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.2c00316

Reference21 articles.

1. The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor

2. AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity

3. Finlay, M. R. V.; Goldberg, F. W.; Ting, A. K. T. Amino-Triazolopyridine Compounds and their Use in Treating Cancer. U.S. Patent US10407446B2, 2019.

4. 20. Hydrazide und Azide organischer Säuren I. Abhandlung

5. Ueber Stickstoffwasserstoffsäure (Azoimid) N 3 H

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