Accelerated Development of a Scalable Synthesis of CY6463, a CNS-Penetrant sGC Stimulator for the Treatment of Neurodegenerative Diseases-Reference-Cited by-同舟云学术

Accelerated Development of a Scalable Synthesis of CY6463, a CNS-Penetrant sGC Stimulator for the Treatment of Neurodegenerative Diseases

Published:2021-09-13 Issue:10 Volume:25 Page:2288-2299
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Wallace Debra J.¹^ORCID,Storz Thomas¹,Balanov Anna¹,Kissel William S.¹

Affiliation:

1. Chemical Development, Cyclerion Therapeutics, Inc., 245 First Street Riverview II, 18th Floor, Cambridge, Massachusetts 02142, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.1c00204

Reference32 articles.

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2. The CNS-Penetrant Soluble Guanylate Cyclase Stimulator CY6463 Reveals its Therapeutic Potential in Neurodegenerative Diseases

3. Rennie, G. R.; Iyengar, R. R.; Lee, T. W.H.; Nakai, T.; Mermerian, A.; Jia, J.; Im, G. Y. J.; Renhowe, P. A.; Jung, J.; Germano, P.; Iyer, K.; Barden, T. C.; Tank, K. Fused Bicyclic SGC Stimulators. U.S. Patent WO2018045276 A1, 2018.

4. Garfunkle, J.; Ornoski, O.; Parker, D. L., Jr; Raghavan, S.; Xu, L.; Yang, Z. Preparation of imidazo-pyrazinyl derivatives useful as soluble guanylate cyclase activators. U.S. Patent WO2016191335 A1, 2016.

5. Diastereoconvergent Negishi Cross-Coupling Using Functionalized Cyclohexylzinc Reagents

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