Regioselective Epoxide Ring Opening for the Stereospecific Scale-Up Synthesis of BMS-960, A Potent and Selective Isoxazole-Containing S1P1 Receptor Agonist-Reference-Cited by-同舟云学术

Regioselective Epoxide Ring Opening for the Stereospecific Scale-Up Synthesis of BMS-960, A Potent and Selective Isoxazole-Containing S1P1 Receptor Agonist

Published:2017-01-25 Issue:2 Volume:21 Page:200-207
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Hou Xiaoping¹^ORCID,Zhang Huiping¹,Chen Bang-Chi¹,Guo Zhiwei²,Singh Amarjit²,Goswami Animesh²,Gilmore John L.¹,Sheppeck James E.¹,Dyckman Alaric J.¹^ORCID,Carter Percy H.¹,Mathur Arvind¹

Affiliation:

1. Discovery Chemistry, Bristol-Myers Squibb, Princeton, New Jersey 08540, United States

2. Chemical & Synthetic Development, Bristol-Myers Squibb, New Brunswick, New Jersey 08903, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.6b00366

Reference19 articles.

1. Selecting against S1P3 enhances the acute cardiovascular tolerability of 3-(N-benzyl)aminopropylphosphonic acid S1P receptor agonists

2. Sphingosine 1-Phosphate (S1P) Receptor Subtypes S1P1 and S1P3, Respectively, Regulate Lymphocyte Recirculation and Heart Rate