A Primer for Pharmaceutical Process Development Chemists and Analysts in Relation to Impurities Perceived to Be Mutagenic or “Genotoxic”

Author:

Snodin David J.1ORCID

Affiliation:

1. Xiphora Biopharma Consulting, 9 Richmond Apartments, Redland Court Road, Bristol BS6 7BG, U.K.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Reference159 articles.

1. ICH M7(R1) on assessment and control of DNA reactive (mutagenic) impurities in pharmaceuticals to limit potential carcinogenic risk. EMA/CHMP/ICH/83812/2013. European Medicines Agency, August 25, 2015. https://www.ema.europa.eu/en/documents/scientific-guideline/ich-guideline-m7r1-assessment-control-dna-reactive-mutagenic-impurities-pharmaceuticals-limit_en.pdf (accessed 2020-07-03).

2. OECD Guideline for Testing of Chemicals. No. 471: Bacterial Reverse Mutation Assay. Organisation for Economic Co-operation and Development (OECD), July 21, 1997. https://www.oecd.org/chemicalsafety/risk-assessment/1948418.pdf (accessed 2020-08-27).

3. The Bacterial Reverse Mutation Test

4. A comparison of Derek and Sarah Nexus. Lhasa Limited, UK, 2017. https://www.lhasalimited.org/Public/Library/2017/A%20comparison%20of%20Derek%20and%20Sarah%20Nexus.pdf (accessed 2020-07-03).

5. Leadscope Model Applier and the ICH M7 Impurities Guidelines. Leadscope, Inc., June 2016. https://www.leadscope.com/faq/LSMA-ICHM7-FAQs-June2016.pdf (accessed 2020-07-03).

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