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Redesign of the Synthesis and Manufacture of an Azetidine-Bearing Pyrazine

  • Published:2018-01-31 Issue:2 Volume:22 Page:241-246
  • ISSN:1083-6160
  • Container-title:Organic Process Research & Development
  • language:en
  • Short-container-title:Org. Process Res. Dev.

Author:

Hose David R. J.1,Hopes Phillip2,Steven Alan1ORCID,Herber Christian3

Affiliation:

1. Pharmaceutical Technology & Development, AstraZeneca, Charter Way, Macclesfield, SK10 2NA, United Kingdom

2. Cyton Biosciences Ltd, 68 Macrae Road, Bristol, BS20 0DD, United Kingdom

3. DOTTIKON Exclusive Synthesis AG, P.O. Box CH - 5605 Dottikon, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Reference12 articles.

1. Property based optimisation of glucokinase activators – discovery of the phase IIb clinical candidate AZD1656

2. aButters, M.; Crabb, J.; Hopes, P.; Patel, B.Process for preparation of benzoyl amino heterocyclic compounds. WO 2010092387, August 19, 2010.

3. bBowden, S. A.; Hoile, D. P.; Lövqvist, K.Crystalline polymorphic form 631. WO 2010092386, August 19, 2010.

4. cBriggner, L.E.; Lindfors, L.; Smith, C. M.Pharmaceutical formulations. WO 2012007758, January 19, 2012.
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