Scalable Process Design for a PDE10A Inhibitor Consisting of Pyrazolopyrimidine and Quinoxaline as Key Units-Reference-Cited by-同舟云学术

Scalable Process Design for a PDE10A Inhibitor Consisting of Pyrazolopyrimidine and Quinoxaline as Key Units

Published:2019-03-15 Issue:4 Volume:23 Page:578-587
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Yamagami Takafumi¹^ORCID,Kobayashi Ryo²,Moriyama Noriaki²,Horiuchi Hideki³,Toyofuku Eiji²,Kadoh Yoichi⁴,Kawanishi Eiji⁵,Izumoto Shinichi⁶,Hiramatsu Hajime⁶,Nanjo Takehiro⁶,Sugino Masuhiro¹,Utsugi Masayuki¹,Moritani Yasunori¹

Affiliation:

1. Process Development Department, Production Technology & Supply Chain Management Division, Mitsubishi Tanabe Pharma Corporation, 3-16-89, Kashima, Yodogawa-ku, Osaka 532-8505, Japan

2. Technology Management Department, Production Technology & Supply Chain Management Division, Mitsubishi Tanabe Pharma Corporation, 3-16-89, Kashima, Yodogawa-ku, Osaka 532-8505, Japan

3. Global Quality Assurance Department, Mitsubishi Tanabe Pharma Corporation, 3-16-89, Kashima, Yodogawa-ku, Osaka 532-8505, Japan

4. Research Unit/Immunology & Inflammation, Sohyaku Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 1000, Kamoshida-cho, Aoba-ku, Yokohama 227-0033, Japan

5. Research Unit/Frontier, Sohyaku Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 2-2-50, Kawagishi, Toda-shi, Saitama 335-8505, Japan

6. Analytical Research Department, Production Technology & Supply Chain Management Division, Mitsubishi Tanabe Pharma Corporation, 3-16-89, Kashima, Yodogawa-ku, Osaka 532-8505, Japan

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.9b00068

Reference29 articles.

1. Cloning and Characterization of a Novel Human Phosphodiesterase That Hydrolyzes Both cAMP and cGMP (PDE10A)

2. Characterization and Phosphorylation of PDE10A2, a Novel Alternative Splice Variant of Human Phosphodiesterase That Hydrolyzes cAMP and cGMP

3. Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A

4. Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions

5. aKawanishi, E.; Hongu, M.; Tanaka, Y. Pyrazolopyrimidine compounds and their use as pde10 inhibitors, WO2011105628A1, 2011.

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