Direct Construction of Chiral Ether via Highly Efficient Heck Reaction and N-Directed Asymmetric Hydrogenation for Large-Scale Synthesis of MALT1 Inhibitor RGT-068A-Reference-Cited by-同舟云学术

Direct Construction of Chiral Ether via Highly Efficient Heck Reaction and N-Directed Asymmetric Hydrogenation for Large-Scale Synthesis of MALT1 Inhibitor RGT-068A

Published:2022-11-03 Issue:11 Volume:26 Page:3089-3095
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Feng Song¹^ORCID,Zhang Haishen²,Tang Zhiyong²,Peng Xingao³,Yang Min¹,Wei Xudong²,Zhong Wenge¹

Affiliation:

1. Regor Therapeutics Group, 1206 Zhangjiang Road, Building C, Zhangjiang Hi-Tech Park, Shanghai 201203, China

2. Pharmaron (Ningbo) Technology Development Co., No. 800 Bin-Hai 4th Road, Hangzhou Bay New Zone, Ningbo 315366, Zhejiang, China

3. BioDuro-Sundia, 388 Jialilue Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.2c00229

Reference20 articles.

1. Crystal structure of the mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) paracaspase region

2. The paracaspase MALT1: biological function and potential for therapeutic inhibition

3. Mucosa-associated lymphoid tissue lymphoma translocation 1 as a novel therapeutic target for rheumatoid arthritis

4. Molecular architecture and regulation of BCL10-MALT1 filaments

5. Malt1 Protease Is Critical in Maintaining Function of Regulatory T Cells and May Be a Therapeutic Target for Antitumor Immunity

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