Process Development of Tryptophan Hydroxylase Inhibitor LX1031, a Drug Candidate for the Treatment of Irritable Bowel Syndrome-Reference-Cited by-同舟云学术

Process Development of Tryptophan Hydroxylase Inhibitor LX1031, a Drug Candidate for the Treatment of Irritable Bowel Syndrome

Published:2020-01-20 Issue:2 Volume:24 Page:261-273
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Zhao Matthew M.¹^ORCID,Zhang Haiming¹^ORCID,Iimura Shinya¹,Bednarz Mark S.¹,Kanamarlapudi Ramanaiah C.¹,Yan Jie¹,Lim Ngiap-Kie¹^ORCID,Wu Wenxue¹^ORCID

Affiliation:

1. Chemical Development, Lexicon Pharmaceutical, Inc., 110 Allen Road, Basking Ridge, New Jersey 07920, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.9b00520

Reference27 articles.

1. Synthesis of Serotonin by a Second Tryptophan Hydroxylase Isoform

2. Modulation of Peripheral Serotonin Levels by Novel Tryptophan Hydroxylase Inhibitors for the Potential Treatment of Functional Gastrointestinal Disorders

3. Burgoon, H. A.; Kanamarlapudi, R.; Pickersgill, I. F.; Shi, Z.C.; Wu, W.; Zhang, H.; Zhao, M. M. Compounds useful in the preparation of tryptophan hydroxylase inhibitors U.S. Patent 8,450,532 B2, 2013.

4. A feasibility study on the synthesis of phenylephrine via ruthenium-catalyzed homogeneous asymmetric hydrogenation

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