Synthesis of 2-Oxopropanethioamide for the Manufacture of Lanabecestat: A New Route for Control, Robustness, and Operational Improvements-Reference-Cited by-同舟云学术

Synthesis of 2-Oxopropanethioamide for the Manufacture of Lanabecestat: A New Route for Control, Robustness, and Operational Improvements

Published:2017-08-07 Issue:9 Volume:21 Page:1404-1412
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Taylor Brian¹,Fernandez Barrat Cristina¹,Woodward Robert L.¹,Inglesby Phillip A.¹^ORCID

Affiliation:

1. Pharmaceutical Development and Technology, AstraZeneca, Silk Road Business Park, Macclesfield, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.7b00170

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5. For the first reported synthesis of lanabecestat, see:Csjernyik, G.; Karlstrom, S.; Kers, A.; Kolmodin, K.; Nylof, M.; Ohberg, L.; Rakos, L.; Sandberg, L.; Sehgelmeble, F.; Soderman, P.; Swahn, B. M.; von Berg, S.Compounds and their use as bace inhibitors. US 20160184303 A1, June 30, 2016.

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