Synthesis of 2-Oxopropanethioamide for the Manufacture of Lanabecestat: A New Route for Control, Robustness, and Operational Improvements-Reference-Cited by-同舟云学术

Synthesis of 2-Oxopropanethioamide for the Manufacture of Lanabecestat: A New Route for Control, Robustness, and Operational Improvements

Published:2017-08-07 Issue:9 Volume:21 Page:1404-1412
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Taylor Brian¹,Fernandez Barrat Cristina¹,Woodward Robert L.¹,Inglesby Phillip A.¹^ORCID

Affiliation:

1. Pharmaceutical Development and Technology, AstraZeneca, Silk Road Business Park, Macclesfield, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.7b00170

Reference18 articles.

1. Î²-secretase inhibitor; a promising novel therapeutic drug in Alzheimerâ€™s disease

2. Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects

3. Targeting the β secretase BACE1 for Alzheimer's disease therapy

4. New Aminoimidazoles as β-Secretase (BACE-1) Inhibitors Showing Amyloid-β (Aβ) Lowering in Brain

5. For the first reported synthesis of lanabecestat, see:Csjernyik, G.; Karlstrom, S.; Kers, A.; Kolmodin, K.; Nylof, M.; Ohberg, L.; Rakos, L.; Sandberg, L.; Sehgelmeble, F.; Soderman, P.; Swahn, B. M.; von Berg, S.Compounds and their use as bace inhibitors. US 20160184303 A1, June 30, 2016.

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A Brief Introduction to Chemical Reaction Optimization;Chemical Reviews;2023-02-23

2. Automation Technologies to Enable Data-Rich Experimentation: Beyond Design of Experiments for Process Modeling in Late-Stage Process Development;Organic Process Research & Development;2021-01-28

3. Spirocyclic Scaffolds in Medicinal Chemistry;Journal of Medicinal Chemistry;2020-12-31

4. Process Development of a Suzuki Reaction Used in the Manufacture of Lanabecestat;Organic Process Research & Development;2018-11-07

5. Process Intensification and Integration Studies for the Generation of a Key Aminoimidazole Intermediate in the Synthesis of Lanabecestat;Organic Process Research & Development;2018-04-26