Scale-up Synthesis of (R)- and (S)-N-(2-Benzoyl-4-chlorophenyl)-1-(3,4-dichlorobenzyl)pyrrolidine-2-carboxamide Hydrochloride, A Versatile Reagent for the Preparation of Tailor-Made α- and β-Amino Acids in an Enantiomerically Pure Form-Reference-Cited by-同舟云学术

Scale-up Synthesis of (R)- and (S)-N-(2-Benzoyl-4-chlorophenyl)-1-(3,4-dichlorobenzyl)pyrrolidine-2-carboxamide Hydrochloride, A Versatile Reagent for the Preparation of Tailor-Made α- and β-Amino Acids in an Enantiomerically Pure Form

Published:2017-04-13 Issue:5 Volume:21 Page:732-739
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Romoff Todd T.¹^ORCID,Palmer Andrew B.¹,Mansour Noel¹,Creighton Christopher J.¹,Miwa Toshio²,Ejima Yuki²,Moriwaki Hiroki²,Soloshonok Vadim A.³⁴

Affiliation:

1. Hamari Chemicals USA, San Diego, California 92121, United States

2. Hamari Chemicals Ltd., 1-4-29 Kunijima, Higashi-Yodogawa-ku, Osaka 53300024, Japan

3. Department of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel Lardizábal 3, 20018 San Sebastián, Spain

4. IKERBASQUE, Basque Foundation for Science, Maria Diaz de Haro 3, 48013 Bilbao, Spain

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.7b00055

Reference91 articles.

1. Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas

2. Recent advances in the trifluoromethylation methodology and new CF3-containing drugs

3. Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

4. Small-Molecule Therapeutics for Ebola Virus (EBOV) Disease Treatment

5. Micro-structured peptide surfaces for the detection of high-affinity peptide–receptor interactions in living cells

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