An Optimized Scalable Fully Automated Solid-Phase Microwave-Assisted cGMP-Ready Process for the Preparation of Eptifibatide

Author:

Sabatino Giuseppina123ORCID,D’Ercole Annunziata124,Pacini Lorenzo145,Zini Matteo4,Ribecai Arianna14,Paio Alfredo14,Rovero Paolo135,Papini Anna Maria1236ORCID

Affiliation:

1. MoD&LS Laboratory, University of Florence, Centre of Competences RISE, Via Madonna del Piano 6, 50019 Sesto Fiorentino, Italy

2. Interdepartmental Research Unit of Peptide and Protein Chemistry and Biology, Department of Chemistry “Ugo Schiff”, University of Florence, Via della Lastruccia 13, 50019 Sesto Fiorentino, Italy

3. CNR-IC Istituto di Cristallografia, Via Paolo Gaifami 18, 95126 Catania, Italy

4. FIS - Fabbrica Italiana Sintetici S.p.A., Viale Milano 26, 36075 Montecchio Maggiore, Vicenza, Italy

5. Interdepartmental Research Unit of Peptide and Protein Chemistry and Biology, Department of Neurosciences, Psychology, Drug Research and Child Health, Section of Pharmaceutical Sciences and Nutraceutics, University of Florence, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Italy

6. PeptLab@UCP Platform of Peptide and Protein Chemistry and Biology, Neuville Campus, CY Cergy Paris Université, 5 mail Gay-Lussac, 95031 Cergy-Pontoise Cedex, France

Funder

Regione Toscana

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

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