1. Laboratory for Medicinal Chemistry Research, Research Division, Shionogi & Co., Ltd., 1-1 Futabacho, 3-Chome, Toyonaka, Osaka 561-0825, Japan
2. API R&D Laboratory, Research Division, Shionogi & Co., Ltd., 1-3 Kuise Terajima, 2-Chome, Amagasaki, Hyogo 660-0813, Japan