From Milligram to Kilogram Manufacture of AZD4573: Making It Possible by Application of Enzyme-, Iridium-, and Palladium-Catalyzed Key Transformations-Reference-Cited by-同舟云学术

From Milligram to Kilogram Manufacture of AZD4573: Making It Possible by Application of Enzyme-, Iridium-, and Palladium-Catalyzed Key Transformations

Published:2021-07-21 Issue: Volume: Page:
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Karlsson Staffan¹^ORCID,Benson Helen²,Cook Calum²,Currie Gordon²,Dubiez Jerome²,Emtenäs Hans¹,Hawkins Janet³,Meadows Rebecca⁴,Smith Peter D.²^ORCID,Varnes Jeffrey⁵

Affiliation:

1. Early Chemical Development, Pharmaceutical Sciences, Biopharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden

2. Early Chemical Development, Pharmaceutical Sciences, Biopharmaceuticals R&D, AstraZeneca, Macclesfield, United Kingdom

3. Medicinal Chemistry, Oncology R&D, AstraZeneca, Cambridge, United Kingdom

4. Chemical Development, Pharmaceutical Technology & Development, Operations, AstraZeneca, Macclesfield, United Kingdom

5. Medicinal Chemistry, Oncology R&D, AstraZeneca, Boston, Massachusetts 02451, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.1c00058

Reference25 articles.

1. Cyclin Dependent Kinase 9 Inhibitors for Cancer Therapy

2. Discovery and Characterization of 2-Anilino-4- (Thiazol-5-yl)Pyrimidine Transcriptional CDK Inhibitors as Anticancer Agents

3. MCL1 and BCL-xL Levels in Solid Tumors Are Predictive of Dinaciclib-Induced Apoptosis

4. AZD4573 Is a Highly Selective CDK9 Inhibitor That Suppresses MCL-1 and Induces Apoptosis in Hematologic Cancer Cells

5. Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies

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