Investigation of On-Resin Disulfide Formation for Large-Scale Manufacturing of Cyclic Peptides: A Case Study
Author:
Affiliation:
1. Chemical Development, Global Pharmaceutical R&D, Ferring Pharmaceuticals A/S, Kay Fiskers Plads 11, DK-2300 Copenhagen S, Denmark
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.0c00168
Reference16 articles.
1. aVarray, S.; Werbitzky, O.; Zeiter, T. On-resin Peptide Cyclization. WO2006/045483A2, 2006.
2. N-Chlorosuccinimide, an Efficient Reagent for On-Resin Disulfide Formation in Solid-Phase Peptide Synthesis
3. Disulfide Formation Strategies in Peptide Synthesis
4. Raising the bar on-bead: Efficient on-resin synthesis of α-conotoxin LvIA
5. Ferring Pharmaceuticals, unpublished work, 2019.
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