Development of an Enantioselective [3 + 2] Cycloaddition To Synthesize the Pyrrolidine Core of ABBV-3221 on Multikilogram Scale-Reference-Cited by-同舟云学术

Development of an Enantioselective [3 + 2] Cycloaddition To Synthesize the Pyrrolidine Core of ABBV-3221 on Multikilogram Scale

Published:2019-09-19 Issue:11 Volume:23 Page:2532-2537
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Hartung John¹^ORCID,Greszler Stephen N.²^ORCID,Klix Russell C.¹,Kallemeyn Jeffrey M.¹

Affiliation:

1. Process Research and Development, AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States

2. Discovery Chemistry and Technology, AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States

Funder

AbbVie

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.9b00292

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5. Altenbach, R. J.; Bogdan, A.; Desroy, N.; Gfesser, G. A.; Greszler, S. N.; Koenig, J. R.; Kym, P. R.; Liu, B.; Scanio, M. J.; Searle, X.; Wang, X.; Yeung, M. C.; Zhao, G. Substituted Pyrrolidines as CFTR Modulators. Intl. Pat. Appl. 2018065962, 2018.

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