Scalable Synthesis of C5aR1 Antagonist ACT-1014-6470 via <i>N</i><sup>7</sup>-Selective Reductive Amination of an Unprotected Pyrazole Starting Material and Intramolecular Urea Formation with 1,1′-Carbonyl-di(1,2,4-triazol) (CDT)-Reference-Cited by-同舟云学术

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Scalable Synthesis of C5aR1 Antagonist ACT-1014-6470 via N⁷-Selective Reductive Amination of an Unprotected Pyrazole Starting Material and Intramolecular Urea Formation with 1,1′-Carbonyl-di(1,2,4-triazol) (CDT)

Published:2024-02-08 Issue:6 Volume:28 Page:2269-2283
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Reber Stefan¹,Blumer Nicole¹,Leuenberger Daniel¹,Fleischer Tony¹,Renneberg Dorte¹,Abele Stefan¹,Schäfer Gabriel¹^ORCID

Affiliation:

1. Chemistry Process R&D, Idorsia Pharmaceuticals Ltd., Hegenheimermattweg 91, CH-4123 Allschwil, Switzerland

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.3c00492

Reference28 articles.

1. The complement system

2. Overview of Complement Activation and Regulation

3. Effect of Severe Renal Impairment on Pharmacokinetics, Safety, and Tolerability of ACT‐1014‐6470, a Novel Oral Complement Factor 5a Receptor 1 Antagonist

4. Preparation of (Cyanomethylene)trimethylphosphorane as a New Mitsunobu-Type Reagent.

5. Nitropyrazoles

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