Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 3: Development of a One-Pot Formylation–Cyclization Sequence to the Diaminopyrimidine Core-Reference-Cited by-同舟云学术

Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 3: Development of a One-Pot Formylation–Cyclization Sequence to the Diaminopyrimidine Core

Published:2020-10-20 Issue:11 Volume:24 Page:2462-2477
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Basu Kallol¹^ORCID,Lehnherr Dan¹^ORCID,Martin Gary E.²^ORCID,Desmond Richard A.¹,Lam Yu-hong³^ORCID,Peng Feng¹^ORCID,Chung John Y. L.¹^ORCID,Arvary Rebecca A.¹,Zompa Michael A.¹,Zhang Si-Wei¹^ORCID,Liu Jinchu¹,Dance Zachary E. X.⁴^ORCID,Larpent Patrick¹,Cohen Ryan D.²^ORCID,Guzman Francisco J.¹,Rogus Nicholas J.¹,Di Maso Michael J.¹^ORCID,Ren Hong¹^ORCID,Maloney Kevin M.¹^ORCID

Affiliation:

1. Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States

2. Structure Elucidation Group, Analytical Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States

3. Computational and Structural Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States

4. Data Rich Measurements, Analytical Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.0c00246

Reference40 articles.

1. P2X3 receptor antagonist (AF-219) in refractory chronic cough: a randomised, double-blind, placebo-controlled phase 2 study

2. Idiopathic Pulmonary Fibrosis

3. Druggable negative allosteric site of P2X3 receptors

4. An update and systematic review on drug therapies for the treatment of refractory chronic cough

5. Update on novel purinergic P2X3 and P2X2/3 receptor antagonists and their potential therapeutic applications

Cited by 9 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. TO MARKET, TO MARKET–2022: SMALL MOLECULES;Medicinal Chemistry Reviews;2023-11-16

2. DELTA50: A Highly Accurate Database of Experimental 1H and 13C NMR Chemical Shifts Applied to DFT Benchmarking;Molecules;2023-03-07

3. Gefapixant Citrate (MK-7264) Sulfonamide Step Speciation Study: Investigation into Precipitation–Dissolution Events during Addition of Chlorosulfonic Acid;Organic Process Research & Development;2023-02-08

4. Green chemistry and sustainability metrics in the pharmaceutical manufacturing sector;Current Opinion in Green and Sustainable Chemistry;2022-02

5. Green and sustainable metrics: Charting the course for green-by-design small molecule API synthesis;Current Research in Green and Sustainable Chemistry;2022