Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 3: Development of a One-Pot Formylation–Cyclization Sequence to the Diaminopyrimidine Core-Reference-Cited by-同舟云学术

Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 3: Development of a One-Pot Formylation–Cyclization Sequence to the Diaminopyrimidine Core

Published:2020-10-20 Issue:11 Volume:24 Page:2462-2477
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Basu Kallol¹^ORCID,Lehnherr Dan¹^ORCID,Martin Gary E.²^ORCID,Desmond Richard A.¹,Lam Yu-hong³^ORCID,Peng Feng¹^ORCID,Chung John Y. L.¹^ORCID,Arvary Rebecca A.¹,Zompa Michael A.¹,Zhang Si-Wei¹^ORCID,Liu Jinchu¹,Dance Zachary E. X.⁴^ORCID,Larpent Patrick¹,Cohen Ryan D.²^ORCID,Guzman Francisco J.¹,Rogus Nicholas J.¹,Di Maso Michael J.¹^ORCID,Ren Hong¹^ORCID,Maloney Kevin M.¹^ORCID

Affiliation:

1. Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States

2. Structure Elucidation Group, Analytical Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States

3. Computational and Structural Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States

4. Data Rich Measurements, Analytical Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.0c00246

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