Synthesis of Lenacapavir Sodium: Active Pharmaceutical Ingredient Process Development and Scale-up-Reference-Cited by-同舟云学术

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Synthesis of Lenacapavir Sodium: Active Pharmaceutical Ingredient Process Development and Scale-up

Published:2024-07-31 Issue:8 Volume:28 Page:3382-3395
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Wagner Anna M.¹^ORCID,Bonderoff Sara A.²,Chang Stanley²,Deignan Jeffrey¹,Esanu Michelle M.²,Van Huynh Huy²,Niu Tianmin²,Ngo Vinh¹,O’Keefe B. Michael¹^ORCID,Phoenix Jenny²,Rainey Trevor J.¹,Roberts Benjamin J.¹,Shen Jinyu²,Stewart Craig²,Vandehey Amanda L.¹,Wolckenhauer Scott A.¹,Wong Chloe Y.¹,Yarmuch Brian H.²

Affiliation:

1. Department of Process Chemistry, Gilead Sciences, 333 Lakeside Drive, Foster City, California 94404, United States

2. Department of Process Chemistry, Gilead Alberta ULC, 1021 Hayter Road NW, Edmonton, Alberta T6S 1A1, Canada

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.4c00242

Reference19 articles.

1. HIV treatment and prevention 2019

2. The global burden of HIV-1 drug resistance in the past 20 years

3. Clinical targeting of HIV capsid protein with a long-acting small molecule

4. Lenacapavir: A Novel, Potent, and Selective First-in-Class Inhibitor of HIV-1 Capsid Function Exhibits Optimal Pharmacokinetic Properties for a Long-Acting Injectable Antiretroviral Agent

5. The Promise of Improved Adherence With Long-Acting Antiretroviral Therapy: What Are the Data?

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