Continuous Flow Process for the Synthesis of Betahistine via Aza-Michael-Type Reaction in Water-Reference-Cited by-同舟云学术

Continuous Flow Process for the Synthesis of Betahistine via Aza-Michael-Type Reaction in Water

Published:2021-04-19 Issue:5 Volume:25 Page:1160-1166
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Sun Maolin¹²,Yang Jingxin¹,Fu Youtian¹,Liang Chaoming¹²,Li Hong¹,Yan Guoming³,Yin Chao³,Yu Wei³,Ma Yueyue¹,Cheng Ruihua⁴,Ye Jinxing¹²^ORCID

Affiliation:

1. Engineering Research Center of Pharmaceutical Process Chemistry, Ministry of Education, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China

2. School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006 China

3. Shanghai Zhongxi Sunve Pharmaceutical Co., Ltd., No. 158 Minle Road, Fengxian District, Shanghai 201419, China

4. School of Chemical Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China

Funder

Ministry of Education of the People's Republic of China

Engineering Research Center of Pharmaceutical Process Chemistry, Ministry of Education

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.0c00543

Reference31 articles.

1. Binding affinity profile of betahistine and its metabolites for central histamine receptors of rodents

2. Histamine and Betahistine in the Treatment of Vertigo

3. Actions of betahistine at histamine receptors in the brain

4. Physiopathology of H, -Receptors and Pharmacology of Betahistine

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