Process Development of a Sonogashira Cross-Coupling Reaction as the Key Step of Tirasemtiv Synthesis Using Design of Experiments
Author:
Affiliation:
1. R&D, Process Chemistry Development, Hovione FarmaCiencia SA, Campus do Lumiar, Building S, 1649-038 Lisboa, Portugal
2. Acadia Pharmaceuticals, Inc., 12830 El Camino Real #400, San Diego, CA 92130, United States
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.0c00524
Reference16 articles.
1. Palladium-Catalyzed Cross-Coupling Reactions in Total Synthesis
2. Recent Applications of Palladium-Catalyzed Coupling Reactions in the Pharmaceutical, Agrochemical, and Fine Chemical Industries
3. Development of a Continuous-Flow Sonogashira Cross-Coupling Protocol using Propyne Gas under Process Intensified Conditions
4. The Sonogashira Reaction: A Booming Methodology in Synthetic Organic Chemistry
5. Sonogashira Reactions with Propyne: Facile Synthesis of 4-Hydroxy-2-methylbenzofurans from Iodoresorcinols
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